Royle, J., Donald, C. L. , Merits, A., Kohl, A. and Varjak, M. (2017) Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. Veterinary Journal, 230, pp. 62-64. (doi: 10.1016/j.tvjl.2017.10.009) (PMID:29102599) (PMCID:PMC5726355)
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Abstract
The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae).
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Royle, Mr Jamie and Donald, Dr Claire and Varjak, Dr Margus and Kohl, Professor Alain |
| Authors: | Royle, J., Donald, C. L., Merits, A., Kohl, A., and Varjak, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Veterinary Journal |
| Publisher: | Elsevier |
| ISSN: | 1090-0233 |
| ISSN (Online): | 1532-2971 |
| Published Online: | 19 October 2017 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in Veterinary Journal 230: 62-64 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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