Baron, M. D., Diop, B., Njeumi, F., Willett, B. J. and Bailey, D. (2017) Future research to underpin successful peste des petits ruminants virus (PPRV) eradication. Journal of General Virology, 98(11), pp. 2635-2644. (doi: 10.1099/jgv.0.000944) (PMID:29022862) (PMCID:PMC5845661)
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Abstract
Peste des petits ruminants virus (PPRV) is a significant pathogen of small ruminants and is prevalent in much of Africa, the Near and Middle East and Asia. Despite the availability of an efficacious and cheap live-attenuated vaccine, the virus has continued to spread, with its range stretching from Morocco in the west to China and Mongolia in the east. Some of the world’s poorest communities rely on small ruminant farming for subsistence and the continued endemicity of PPRV is a constant threat to their livelihoods. Moreover, PPRV’s effects on the world’s population are felt broadly across many economic, agricultural and social situations. This far-reaching impact has prompted the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) to develop a global strategy for the eradication of this virus and its disease. PPRV is a morbillivirus and, given the experience of these organizations in eradicating the related rinderpest virus, the eradication of PPRV should be feasible. However, there are many critical areas where basic and applied virological research concerning PPRV is lacking. The purpose of this review is to highlight areas where new research could be performed in order to guide and facilitate the eradication programme. These areas include studies on disease transmission and epidemiology, the existence of wildlife reservoirs and the development of next-generation vaccines and diagnostics. With the support of the international virology community, the successful eradication of PPRV can be achieved.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Willett, Professor Brian |
Authors: | Baron, M. D., Diop, B., Njeumi, F., Willett, B. J., and Bailey, D. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Journal of General Virology |
Publisher: | Microbiology Society |
ISSN: | 0022-1317 |
ISSN (Online): | 1465-2099 |
Published Online: | 12 October 2017 |
Copyright Holders: | Copyright © 2017 The Authors |
First Published: | First published in Journal of General Virology 98(11):2635-2644 |
Publisher Policy: | Reproduced under a Creative Commons License |
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