Morreale, F. E. and Walden, H. (2016) Types of ubiquitin ligases. Cell, 165(1), 248-248.e1. (doi: 10.1016/j.cell.2016.03.003) (PMID:27015313)
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Abstract
Ubiquitination is a post-translational modification of proteins involved in a variety of cellular processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases). This SnapShot highlights the main types of E3 ubiquitin ligases, which can be classified in three families depending on the presence of characteristic domains and on the mechanism of ubiquitin transfer to the substrate protein.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Walden, Professor Helen |
Authors: | Morreale, F. E., and Walden, H. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Cell |
Publisher: | Elsevier (Cell Press) |
ISSN: | 0092-8674 |
ISSN (Online): | 1097-4172 |
Published Online: | 24 March 2016 |
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