Myocardial changes in incident haemodialysis patients over 6-months: an observational cardiac magnetic resonance imaging study

Rutherford, E. et al. (2017) Myocardial changes in incident haemodialysis patients over 6-months: an observational cardiac magnetic resonance imaging study. Scientific Reports, 7, 13976. (doi: 10.1038/s41598-017-14481-y) (PMID:29070834) (PMCID:PMC5656609)

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Patients commencing on haemodialysis (HD) have an increased risk of cardiovascular events in the first year after starting HD compared to those patients established on HD longer. Left ventricular (LV) hypertrophy and abnormal myocardial strain predict mortality. There may be changes in the myocardium of incident HD patients over a 6-month period of HD which may explain changes in cardiovascular risk. We used CMR to consider changes in LV mass, myocardial strain and T1 mapping. We examined changes in pre-dialysis highly sensitive troponin T. 33 patients undergoing HD for <12 months were recruited. Participants underwent CMR at baseline and after 6-months of standard care. 6-months of HD was associated with reduction in LV mass index (Baseline: 78.8 g/m2 follow up: 69.9 g/m2, p = <0.001). LV global longitudinal strain also improved (Baseline: −17.9%, follow up: −21.6%, p = <0.001). Change in T1 time was not significant (Baseline septal T1 1277.4 ms, follow up 1271.5 p = 0.504). Highly sensitive troponin T was lower at follow up (Baseline 38.8 pg/L, follow up 30.8 pg/L p = 0.02). In incident HD patients, 6-months of HD was associated with improvements in LV mass, strain and troponin. These findings may reflect improvement in known cardiac tissue abnormalities found in patients over the first year of HD.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Patel, Dr Rajan and Mccomb, Dr Christie and Mangion, Dr Kenneth and Rutherford, Dr Elaine and Woodward, Miss Rosemary and Roditi, Dr Giles and Mark, Professor Patrick and Welsh, Dr Paul and Berry, Professor Colin and Jardine, Professor Alan and Radjenovic, Dr Aleksandra
Authors: Rutherford, E., Mangion, K., Mccomb, C., Bell, E., Cockburn, S., Talle, M., Roditi, G., Welsh, P., Woodward, R., Radjenovic, A., Struthers, A. D., Jardine, A., Berry, C., Patel, R. K., and Mark, P. B.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Scientific Reports 7:13976
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
699321Myocardial strain measurements in survivors of acute ST-elevation myocardial infarction: implementation and prognostic significance of novel magnetic resonance imaging methods.Colin BerryBritish Heart Foundation (BHF)FS/15/54/31639RI CARDIOVASCULAR & MEDICAL SCIENCES