Tumor stiffness extends its grip on the metastatic microenvironment

Reid, S. E. and Zanivan, S. (2017) Tumor stiffness extends its grip on the metastatic microenvironment. Molecular and Cellular Oncology, 4(6), e1372866. (doi: 10.1080/23723556.2017.1372866)

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The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels. This permits more stable interactions with cancer cells and increases their ability to spread into the circulation.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Zanivan, Professor Sara
Authors: Reid, S. E., and Zanivan, S.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Molecular and Cellular Oncology
Publisher:Taylor and Francis
ISSN (Online):2372-3556
Published Online:16 October 2017
Copyright Holders:Copyright © 2017 Steven E. Reid and Sara Zanivan
First Published:First published in Molecular and Cellular Oncology 4(6): e1372866
Publisher Policy:Reproduced under a Creative Commons License

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