Reid, S. E. and Zanivan, S. (2017) Tumor stiffness extends its grip on the metastatic microenvironment. Molecular and Cellular Oncology, 4(6), e1372866. (doi: 10.1080/23723556.2017.1372866)
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Abstract
The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels. This permits more stable interactions with cancer cells and increases their ability to spread into the circulation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Zanivan, Professor Sara |
Authors: | Reid, S. E., and Zanivan, S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Molecular and Cellular Oncology |
Publisher: | Taylor and Francis |
ISSN: | 2372-3556 |
ISSN (Online): | 2372-3556 |
Published Online: | 16 October 2017 |
Copyright Holders: | Copyright © 2017 Steven E. Reid and Sara Zanivan |
First Published: | First published in Molecular and Cellular Oncology 4(6): e1372866 |
Publisher Policy: | Reproduced under a Creative Commons License |
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