Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications

Giaginis, C. T., Zarros, A. C. , Papaefthymiou, M. A., Papadopouli, A. E., Sfiniadakis, I. K. and Theocharis, S. E. (2008) Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications. World Journal of Surgical Oncology, 6, 59. (doi: 10.1186/1477-7819-6-59) (PMID:18558015) (PMCID:PMC2440381)

149154.pdf - Published Version
Available under License Creative Commons Attribution.



The coxsackievirus and adenovirus receptor (CAR) is a crucial receptor for the entry of both coxsackie B viruses and adenoviruses into host cells. CAR expression on tumor cells was reported to be associated with their sensitivity to adenoviral infection, while it was considered as a surrogate marker for monitoring and/or predicting the outcome of adenovirus-mediated gene therapy. The aim of the present study was to evaluate the clinical significance of CAR expression in endometrial adenocarcinoma. CAR expression was assessed immunohistochemically in tumoral samples of 41 endometrial adenocarcinoma patients and was statistically analyzed in relation to various clinicopathological parameters, tumor proliferative capacity and patient survival. CAR positivity was noted in 23 out of 41 (56%) endometrial adenocarcinoma cases, while high CAR expression in 8 out of 23 (35%) positive ones. CAR intensity of immunostaining was classified as mild in 11 (48%), moderate in 10 (43%) and intense in 2 (9%) out of the 23 positive cases. CAR positivity was significantly associated with tumor histological grade (p = 0.036), as well differentiated tumors more frequently demonstrating no CAR expression. CAR staining intensity was significantly associated with tumor histological type (p = 0.016), as tumors possessing squamous elements presented more frequently intense CAR immunostaining. High CAR expression showed a trend to be correlated with increased tumor proliferative capacity (p = 0.057). Patients with tumors presenting moderate or intense CAR staining intensity were characterized by longer survival times than those with mild one; however, this difference did not reach statistical significance. These data reveal, for the first time, the expression of CAR in clinical material obtained from patients with endometrial adenocarcinoma in relation to important clinicopathological parameters for their management. As CAR appears to modulate the proliferation and characteristics of cancer cells, its expression could be considered of possible clinical importance for future (gene) therapy applications.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Zarros, Dr Apostolos
Authors: Giaginis, C. T., Zarros, A. C., Papaefthymiou, M. A., Papadopouli, A. E., Sfiniadakis, I. K., and Theocharis, S. E.
Subjects:R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RG Gynecology and obstetrics
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:World Journal of Surgical Oncology
Publisher:BioMed Central
ISSN (Online):1477-7819
Copyright Holders:Copyright © 2008 Giaginis et al.
First Published:First published in World Journal of Surgical Oncology 6: 59
Publisher Policy:Reproduced under a Creative Commons license

University Staff: Request a correction | Enlighten Editors: Update this record