Choline deprivation: an overview of the major hepatic metabolic response pathways

Al-Humadi, H., Zarros, A. , Kyriakaki, A., Al-Saigh, R. and Liapi, C. (2012) Choline deprivation: an overview of the major hepatic metabolic response pathways. Scandinavian Journal of Gastroenterology, 47(8-9), pp. 874-886. (doi: 10.3109/00365521.2012.685755) (PMID:22571353)

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Choline (Ch) is an important nutrient that is involved in many physiological functions. Deprivation of Ch (CD) may lead to hepatocellular modifications and/or even hepatic tumorigenesis and it can be a frequent problem in clinical settings; it can accompany various common pathological (alcoholism and malnutrition) or physiological states (pregnancy and lactation). The aim of this review is to provide an up-to-date overview of the major metabolic pathways involved in the hepatic response toward the experimentally or clinically induced CD, and to shed more light on the implicated (and probably interrelated) mechanisms responsible for the observed hepatocellular modifications and/or carcinogenesis.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Zarros, Dr Apostolos
Authors: Al-Humadi, H., Zarros, A., Kyriakaki, A., Al-Saigh, R., and Liapi, C.
Subjects:R Medicine > RB Pathology
R Medicine > RC Internal medicine
R Medicine > RZ Other systems of medicine
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Scandinavian Journal of Gastroenterology
Publisher:Informa Healthcare
ISSN (Online):1502-7708
Published Online:10 May 2012

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