Bartley, K., Turnbull, F. , Wright, H. W., Huntley, J. F., Palarea-Albaladejo, J., Nath, M. and Nisbet, A. J. (2017) Field evaluation of poultry red mite ( Dermanyssus gallinae ) native and recombinant prototype vaccines. Veterinary Parasitology, 244, pp. 25-34. (doi: 10.1016/j.vetpar.2017.06.020) (PMID:28917313)
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Abstract
Vaccination is a desirable emerging strategy to combat poultry red mite (PRM), Dermanyssus gallinae. We performed trials, in laying hens in a commercial-style cage facility, to test the vaccine efficacy of a native preparation of soluble mite extract (SME) and of a recombinant antigen cocktail vaccine containing bacterially-expressed versions of the immunogenic SME proteins Deg-SRP-1, Deg-VIT-1 and Deg-PUF-1. Hens (n = 384 per group) were injected with either vaccine or adjuvant only (control group) at 12 and 17 weeks of age and then challenged with PRM 10 days later. PRM counts were monitored and, at the termination of the challenge period (17 weeks post challenge), average PRM counts in cages containing birds vaccinated with SME were reduced by 78% (p < 0.001), compared with those in the adjuvant-only control group. When the trial was repeated using the recombinant antigen cocktail vaccine, no statistically significant differences in mean PRM numbers were observed in cages containing vaccinated or adjuvant-only immunised birds. The roles of antigen-specific antibody levels and duration in providing vaccine-induced and exposure-related protective immunity are discussed.
| Item Type: | Articles |
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| Additional Information: | The authors gratefully acknowledge funding for this project from Scottish Government and BBRSC (grant reference BB/J01513X/1), Zoetis and Akita Co. Ltd., The British Egg Marketing Board Trust and Genomia. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Turnbull, Dr Frank and Nisbet, Dr Alasdair |
| Authors: | Bartley, K., Turnbull, F., Wright, H. W., Huntley, J. F., Palarea-Albaladejo, J., Nath, M., and Nisbet, A. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Veterinary Parasitology |
| Publisher: | Elsevier |
| ISSN: | 0304-4017 |
| ISSN (Online): | 1873-2550 |
| Published Online: | 27 June 2017 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in Veterinary Parasitology 244: 25-34 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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