Epigenetics and immunometabolism in diabetes and aging

Guzik, T. J. and Cosentino, F. (2018) Epigenetics and immunometabolism in diabetes and aging. Antioxidants and Redox Signaling, 29(3), pp. 257-274. (doi: 10.1089/ars.2017.7299) (PMID:28891325) (PMCID:PMC6012980)

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Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation. Immunometabolic pathways link these pathogenic processes and pose important potential therapeutic targets. Recent Advances: The link between immunity and metabolism is bi-directional and includes the role of inflammation in the pathogenesis of metabolic disorders such as T2D, obesity, metabolic syndrome and hypertension as well as the role of metabolic factors in regulation of immune cell functions. Low-grade inflammation, oxidative stress, balance between superoxide and nitric oxide, and the infiltration of macrophages, T cells, B cells in insulin-sensitive tissues, leads to metabolic impairment and accelerated ageing. Critical Issues: Inflammatory infiltrate and altered immune cell phenotype precede development of metabolic disorders. Inflammatory changes are tightly linked to alterations in metabolic status and energy expenditure and are controlled by epigenetic mechanisms. Future directions: A better comprehension of these mechanistic insights is of utmost importance to identify novel molecular targets. Here, we describe a complex scenario of epigenetic changes and immunometabolism linking to diabetes and aging-associated vascular disease.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Guzik, Professor Tomasz
Authors: Guzik, T. J., and Cosentino, F.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Antioxidants and Redox Signaling
Publisher:Mary Ann Liebert
ISSN (Online):1557-7716
Published Online:11 September 2017
Copyright Holders:Copyright © 2017 Tomasz J. Guzik and Francesco Cosentino
First Published:First published in Antioxidants and Redox Signaling 29(3): 257-274
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
651771ImmunoTensionTomasz GuzikEuropean Commission (EC)631773RI CARDIOVASCULAR & MEDICAL SCIENCES
617771BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177RI CARDIOVASCULAR & MEDICAL SCIENCES