Read, S.H. et al. (2018) Incident ischaemic stroke and Type 2 diabetes: trends in incidence and case fatality in Scotland 2004–2013. Diabetic Medicine, 35(1), pp. 99-106. (doi: 10.1111/dme.13528) (PMID:29044687)
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Abstract
Aim: To describe trends in first ischaemic stroke incidence and case fatality in adults with and without a diagnosis of Type 2 diabetes prior to their ischaemic stroke event in Scotland between 2004 and 2013. Methods: Using population-wide hospital admission, death and diabetes datasets, we conducted a retrospective cohort study. Negative binomial and logistic regression models were used to calculate year-specific incidence and case-fatality rates for people with Type 2 diabetes and for people without diabetes. Results: During 41.0 million person-years of follow-up there were 69 757 ischaemic stroke events. Type 2 diabetes prevalence among patients who experienced ischaemic stroke increased from 13.5% to 20.3% between 2004 and 2013. Stroke incidence rates declined by 2.7% (95% CI 2.4, 3.0) annually for people with and without diabetes [diabetes/year interaction: rate ratio 0.99 (95% CI 0.98, 1.01)]. Type 2 diabetes was associated with an increased risk of ischaemic stroke in men [rate ratio 1.23 (95% CI 1.17, 1.30)] and women [rate ratio 1.41 (95% CI 1.35, 1.48)]. Case-fatality rates were 14.2% and 12.7% in people with Type 2 diabetes and without diabetes, respectively. Case fatality declined by 3.5% (95% CI 2.7, 4.5) annually [diabetes/year interaction: odds ratio 1.01 (95% CI 0.98, 1.02)]. Conclusions: Ischaemic stroke incidence declined no faster in people with a diagnosis of Type 2 diabetes than in people without diabetes. Increasing prevalence of Type 2 diabetes among stroke patients may mean that declines in case fatality over time will be less marked in the future.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lindsay, Dr Robert and McAllister, Professor David and Sattar, Professor Naveed |
Authors: | Read, S.H., McAllister, D.A., Colhoun, H.M., Farran, B., Fischbacher, C., Kerssens, J.J., Leese, G.P., Lindsay, R.S., McCrimmon, R.J., McGurnaghan, S., Philip, S., Sattar, N., and Wild, S.H. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
Journal Name: | Diabetic Medicine |
Publisher: | Wiley |
ISSN: | 0742-3071 |
ISSN (Online): | 1464-5491 |
Published Online: | 17 October 2017 |
Copyright Holders: | Copyright © 2017 Diabetes UK |
First Published: | First published in Diabetic Medicine 35(1): 99-106 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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