Gestational diabetes mellitus- right person, right treatment, right time?

Lindsay, R. S. , Mackin, S. T. and Nelson, S. M. (2017) Gestational diabetes mellitus- right person, right treatment, right time? BMC Medicine, 15, 163. (doi: 10.1186/s12916-017-0925-2) (PMID:28844206) (PMCID:PMC5572161)

Abstract

Background: Personalised treatment that is uniquely tailored to an individual’s phenotype has become a key goal of clinical and pharmaceutical development across many, particularly chronic, diseases. For type 2 diabetes, the importance of the underlying clinical heterogeneity of the condition is emphasised and a range of treatments are now available, with personalised approaches being developed. While a close connection between risk factors for type 2 diabetes and gestational diabetes has long been acknowledged, stratification of screening, treatment and obstetric intervention remains in its infancy. Conclusions: Although there have been major advances in our understanding of glucose tolerance in pregnancy and of the benefits of treatment of gestational diabetes, we argue that far more vigorous approaches are needed to enable development of companion diagnostics, and to ensure the efficacious and safe use of novel therapeutic agents and strategies to improve outcomes in this common condition.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lindsay, Dr Robert and Mackin, Dr Sharon and Nelson, Professor Scott
• Authors: Lindsay, R. S., Mackin, S. T., and Nelson, S. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: BMC Medicine
• Publisher: BioMed Central
• ISSN: 1741-7015
• ISSN (Online): 1741-7015
• Copyright Holders: Copyright © 2017 The Authors
• First Published: First published in BMC Medicine 15: 163
• Publisher Policy: Reproduced under a Creative Commons license