Luminally expressed gastrointestinal biomarkers

Cummins, G., Yung, D. E., Cox, B. F., Koulaouzidis, A., Desmulliez, M. P.Y. and Cochran, S. (2017) Luminally expressed gastrointestinal biomarkers. Expert Review of Gastroenterology and Hepatology, 11(12), pp. 1119-1134. (doi:10.1080/17474124.2017.1373017) (PMID:28849686)

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Abstract

Introduction: A biomarker is a measurable indicator of normal biologic processes, pathogenic processes or pharmacological responses. The identification of a useful biomarker is challenging, with several hurdles to overcome before clinical adoption. This review gives a general overview of a range of biomarkers associated with inflammatory bowel disease or colorectal cancer along the gastrointestinal tract. Areas covered: These markers include those that are already clinically accepted, such as inflammatory markers such as faecal calprotectin, S100A12 (Calgranulin C), Fatty Acid Binding Proteins (FABP), malignancy markers such as Faecal Occult Blood, Mucins, Stool DNA, Faecal microRNA (miRNA), other markers such as Faecal Elastase, Faecal alpha-1-antitrypsin, Alpha2-macroglobulin and possible future markers such as microbiota, volatile organic compounds and pH. Expert commentary: There are currently a few biomarkers that have been sufficiently validated for routine clinical use at present such as FC. However, many of these biomarkers continue to be limited in sensitivity and specificity for various GI diseases. Emerging biomarkers have the potential to improve diagnosis and monitoring but further study is required to determine efficacy and validate clinical utility.

Item Type:Articles
Keywords:Hepatology, gastroenterology.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cox, Dr Benjamin F and Cochran, Professor Sandy
Authors: Cummins, G., Yung, D. E., Cox, B. F., Koulaouzidis, A., Desmulliez, M. P.Y., and Cochran, S.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:Expert Review of Gastroenterology and Hepatology
Publisher:Taylor and Francis
ISSN:1747-4124
ISSN (Online):1747-4132
Published Online:29 August 2017
Copyright Holders:Copyright © 2017 Taylor and Francis
First Published:First published in Expert Review of Gastroenterology and Hepatology 11(12): 1119-1134
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
615381Sonopill: minimally invasive gastrointestinal diagnosis and therapyDavid CummingEngineering and Physical Sciences Research Council (EPSRC)EP/K034537/1ENG - ENGINEERING ELECTRONICS & NANO ENG