Sutherland, M. and Porr, B. (2016) Modelling the Effect of Dorsal Raphe Serotonin Neurons on Patience for Future Rewards. In: 14th International Conference on Simulation of Adaptive Behavior (SAB 2016), Aberystwyth, UK, 23-26 Aug 2016, pp. 256-266. ISBN 9783319434872 (doi: 10.1007/978-3-319-43488-9_23)
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Abstract
Serotonin is a neurotransmitter that is implicated in many basic human functions and behaviours and is closely associated with happiness, depression and reward processing. In particular it appears to be involved in suppressing responses to distracting stimuli while waiting for a delayed reward. Here we present a system level model of the limbic system which is able to generate a serotonin (5-hydroxytryptamine [5HT]) signal so that a simulated animal waits for a delayed reward. We propose that the 5HT signal is computed by a network involving the medial Orbital Frontal Cortex (mOFC), medial Pre Frontal Cortex (mPFC), Dorsal Raphe Nucleus (DRN)and the Nucleus Accumbens Core (NAcc). The serotonin signal encodes pre-reward liking, motivation throughout the trial and delayed reward waiting. We have successfully replicated the behaviour and dynamics of laboratory studies. With the help of this model we can predict that low levels of serotonin indirectly cause less encountered rewards because the animal gives up too early.
| Item Type: | Conference Proceedings |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | SUTHERLAND, MARC and Porr, Dr Bernd |
| Authors: | Sutherland, M., and Porr, B. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| ISBN: | 9783319434872 |
| Published Online: | 10 August 2016 |
| Copyright Holders: | Copyright © 2016 Springer International Publishing Switzerland |
| First Published: | First published in 14th International Conference on Simulation of Adaptive Behavior (SAB 2016): 256-266 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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