Hybrid localized surface plasmon resonance and quartz crystal microbalance sensor for label free biosensing

Hao, D., Hu, C. , Grant, J. , Glidle, A. and Cumming, D. R.S. (2018) Hybrid localized surface plasmon resonance and quartz crystal microbalance sensor for label free biosensing. Biosensors and Bioelectronics, 100, pp. 23-27. (doi: 10.1016/j.bios.2017.08.038) (PMID:28850824)

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We report on the design and fabrication of a hybrid sensor that integrates transmission-mode localized surface plasmonic resonance (LSPR) into a quartz crystal microbalance (QCM) for studying biochemical surface reactions. The coupling of LSPR nanostructures and a QCM allows optical spectra and QCM resonant frequency shifts to be recorded simultaneously and analyzed in real time for a given surface adsorption process. This integration simplifies the conventional combination of SPR and QCM and has the potential to be miniaturized for application in point-of-care (POC) diagnostics. The influence of antibody-antigen recognition effect on both the QCM and LSPR has been analyzed and discussed.``

Item Type:Articles
Glasgow Author(s) Enlighten ID:Cumming, Professor David and Glidle, Dr Andrew and Hao, Danni and Grant, Dr James and Hu, Dr Chunxiao
Authors: Hao, D., Hu, C., Grant, J., Glidle, A., and Cumming, D. R.S.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Biosensors and Bioelectronics
ISSN (Online):1873-4235
Published Online:31 August 2017
Copyright Holders:Copyright © 2017 Elsevier B.V.
First Published:First published in Biosensors and Bioelectronics 100:23-27
Publisher Policy:Reproduced under a Creative Commons License
Data DOI:10.5525/gla.researchdata.447

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
605821The Multi-Corder: Poly-Sensor TechnologyDavid CummingEngineering and Physical Sciences Research Council (EPSRC)EP/K021966/1ENG - ENGINEERING ELECTRONICS & NANO ENG