Clinical and laboratory features of human herpesvirus 6 chromosomal integration

Clark, D.A. (2016) Clinical and laboratory features of human herpesvirus 6 chromosomal integration. Clinical Microbiology and Infection, 22(4), pp. 333-339. (doi: 10.1016/j.cmi.2015.12.022) (PMID:26802216)

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Human herpesvirus 6 (HHV-6) comprises two separate viruses, HHV-6A and HHV-6B, although this distinction is not commonly made. HHV-6B is ubiquitous in the population with primary infection usually occurring in early childhood, and often resulting in febrile illness. HHV-6B is also recognized as a pathogen in the immunocompromised host, particularly in transplant recipients. HHV-6A is less well characterized and may have a more restricted prevalence. Both viruses are unique among the human herpesviruses in that the entire viral genome can be found integrated into the telomeric regions of host cell chromosomes. Approximately 1% of persons have inherited integrated viral sequences through the germline, and these individuals characteristically have very high viral loads in blood and other sample types. Emerging evidence suggests that HHV-6A and HHV-6B chromosomal integration may not just be an uncommon biological observation, but more likely a characteristic of the replication properties of these viruses. The integrated viral genome appears capable of excision from the chromosomal site and potentially allows viral replication. The clinical consequences of inherited chromosomally integrated HHV-6 have yet to be fully appreciated.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Clark, Dr Duncan
Authors: Clark, D.A.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Clinical Microbiology and Infection
ISSN (Online):1469-0691
Published Online:20 January 2016

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