Ward, K. N., Leong, H. N., Nacheva, E. P., Howard, J., Atkinson, C. E., Davies, N. W. S., Griffiths, P. D. and Clark, D. A. (2006) Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles. Journal of Clinical Microbiology, 44(4), pp. 1571-1574. (doi: 10.1128/JCM.44.4.1571-1574.2006) (PMID:16597897) (PMCID:PMC1448653)
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Abstract
Six immunocompetent patients with human herpesvirus 6 (HHV-6) chromosomal integration had HHV-6 and β-globin DNA quantified in various samples by PCR. The mean HHV-6 DNA concentration (log10 copies/milliliter) in blood was 7.0 (≥1 HHV-6 DNA copies/leukocyte), and in serum it was 5.3 (≥1 HHV-6 DNA copies/lysed cell). The mean HHV-6 DNA load (log10 copies)/hair follicle was 4.2 (≥1 copies/hair follicle cell), demonstrating that viral integration is not confined to blood cells. The characteristically high HHV-6 DNA levels in chromosomal integration may confound laboratory diagnosis of HHV-6 infection and should be given due consideration.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Clark, Dr Duncan |
| Authors: | Ward, K. N., Leong, H. N., Nacheva, E. P., Howard, J., Atkinson, C. E., Davies, N. W. S., Griffiths, P. D., and Clark, D. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | Journal of Clinical Microbiology |
| Publisher: | American Society for Microbiology |
| ISSN: | 0095-1137 |
| ISSN (Online): | 1098-660X |
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