The roles of buffers in body fluids: mathematical analysis

Burton, R.F. (1973) The roles of buffers in body fluids: mathematical analysis. Respiration Physiology, 18(1), pp. 34-42. (doi: 10.1016/0034-5687(73)90020-0) (PMID:4713851)

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Differential equations are given that relate changes in pH, carbon dioxide tension, bicarbonate and total carbon dioxide content to each other and to the buffer values of bicarbonate and carbonate, both free and complexed, and of the other buffers in physiological buffer systems. Also considered are the effects of adding strong acid or base when either the tension or content of carbon dioxide is held constant, of adding or removing water, and, with special reference to the effects of temperature, of changes in buffer dissociation constants. Various potential sources of confusion in the literature are discussed and also the sometimes contrasting roles of different buffer substances. Thus, for instance, whilst the action of non-bicarbonate buffers at constant temperature is always to increase the stability of pH, that of bicarbonate may, according to circumstances, be to increase it, diminish it, or leave it unaffected.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Burton, Dr Richard
Authors: Burton, R.F.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Respiration Physiology
Publisher:North-Holland Publishing Company

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