Schmitz, L., Gambichler, T., Gupta, G., Stücker, M., Stockfleth, E., Szeimies, R.M. and Dirschka, T. (2018) Actinic keratoses show variable histological basal growth patterns - a proposed classification adjustment. Journal of the European Academy of Dermatology and Venereology, 32(5), pp. 745-751. (doi: 10.1111/jdv.14512) (PMID:28796914)
|
Text
145893.pdf - Accepted Version 880kB |
Abstract
Background: Common histological classification schemes of actinic keratoses (AK) do not evaluate growth patterns at basal epidermal aspects of AK. Until now, the importance of basal epidermal growth patterns of AK has not been studied. Objective: To investigate the extent of atypical keratinocytes throughout the epidermis and variation in basal growth patterns of AK. Methods: AK lesions occurring on the head/face from patients seen in routine practice were assessed histologically. We determined histological grade (AK I-III), basal growth patterns of atypical keratinocytes (crowding, budding, papillary sprouting) and accompanying parameters. Results: Of the 246 lesions included, 28.0% were histologically classified as AK I, 46.7% as AK II, and 25.2% as AK III. 26.4% of the basal growth patterns were classified as crowding (pro I), 49.6% as budding (pro II), 17.9% as papillary sprouting (pro III) and 6.1% without basal directed growth. No significant correlation of the histological AK I-III grading and underlying growth patterns was observed (P= 0.4666). However, adnexal structure involvement (OR= 2.37; 95%CI 1.21-4.65), infiltration (OR= 2.53; 95%CI 1.31-4.90) and increased number of vessels (OR= 2.56; 95%CI 1.42-4.65) were independent positive predictive markers for pro II and pro III basal growth patterns. Conclusions: Basal growth patterns (pro I-III) in AK do not correlate with the established AK I-III histological grading system. Besides the degree of upward extension, varying degrees of downward extension exist. Histological classification should consider both, upwards and downward growth patterns when assessing AK.
| Item Type: | Articles |
|---|---|
| Keywords: | Actinic keratosis, squamous cell carcinoma, histological classification, KIN, basal directed growth. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gupta, Dr Girish |
| Authors: | Schmitz, L., Gambichler, T., Gupta, G., Stücker, M., Stockfleth, E., Szeimies, R.M., and Dirschka, T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Journal of the European Academy of Dermatology and Venereology |
| Publisher: | Wiley |
| ISSN: | 0926-9959 |
| ISSN (Online): | 1468-3083 |
| Published Online: | 16 October 2017 |
| Copyright Holders: | Copyright © 2017 European Academy of Dermatology and Venereology |
| First Published: | First published in Journal of the European Academy of Dermatology and Venereology 32(5):745-751 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details