GBM radiosensitizers: dead in the water…or just the beginning?

Bindra, R. S., Chalmers, A. J. , Evans, S. and Dewhirst, M. (2017) GBM radiosensitizers: dead in the water…or just the beginning? Journal of Neuro-Oncology, 134(3), pp. 513-521. (doi: 10.1007/s11060-017-2427-7) (PMID:28762004)

Abstract

The finding that most GBMs recur either near or within the primary site after radiotherapy has fueled great interest in the development of radiosensitizers to enhance local control. Unfortunately, decades of clinical trials testing a wide range of novel therapeutic approaches have failed to yield any clinically viable radiosensitizers. However, many of  the previous radiosensitizing strategies were not based on clear pre-clinical evidence, and in many cases blood-barrier penetration was not considered. Furthermore, DNA repair inhibitors have only recenly arrived in the clinic, and likely represent potent agents for glioma radiosensitization. Here, we present recent progress in the use of small molecule DNA damage response inhibitors as GBM radiosensitizers. In addition, we discuss the latest progress in targeting hypoxia and oxidative stress for GBM radiosensitization.

• Item Type: Articles
• Keywords: DNA damage response, DNA repair, hypoxia, radiosensitizer.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Chalmers, Professor Anthony
• Authors: Bindra, R. S., Chalmers, A. J., Evans, S., and Dewhirst, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Journal of Neuro-Oncology
• Publisher: Springer
• ISSN: 0167-594X
• ISSN (Online): 1573-7373
• Published Online: 31 July 2017
• Copyright Holders: Copyright © 2017 Springer Science+Business Media
• First Published: First published in Journal of Neuro-Oncology 134(3): 513-521
• Publisher Policy: Reproduced in accordance with the publisher copyright policy