Cardenas-Rodriguez, M. and Tokatlidis, K. (2017) Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space. FEBS Letters, 591(17), pp. 2661-2670. (doi: 10.1002/1873-3468.12766) (PMID:28746987) (PMCID:PMC5601281)
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Abstract
Oxidative protein folding is confined to the bacterial periplasm, endoplasmic reticulum and the mitochondrial intermembrane space. Maintaining a redox balance requires the presence of reductive pathways. The major thiol-reducing pathways engage the thioredoxin and the glutaredoxin systems which are involved in removal of oxidants, protein proofreading and folding. Alterations in redox balance likely affect the flux of these redox pathways and are related to ageing and diseases such as neurodegenerative disorders and cancer. Here, we first review the well-studied oxidative and reductive processes in the bacterial periplasm and the endoplasmic reticulum, and then discuss the less understood process in the mitochondrial intermembrane space, highlighting its importance for the proper function of the cell.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cardenas Rodriguez, Mr Mauricio and Tokatlidis, Professor Kostas |
| Authors: | Cardenas-Rodriguez, M., and Tokatlidis, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | FEBS Letters |
| Publisher: | Wiley |
| ISSN: | 0014-5793 |
| ISSN (Online): | 1873-3468 |
| Published Online: | 26 July 2017 |
| First Published: | First published in FEBS Letters 591(17):2661–2670 |
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