Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole

Sherry, L. , Kean, R., McKloud, E., O'Donnell, L. E., Metcalfe, R., Jones, B. L. and Ramage, G. (2017) Biofilms formed by isolates from recurrent vulvovaginal candidiasis patients are heterogeneous and insensitive to fluconazole. Antimicrobial Agents and Chemotherapy, 61(9), e01065-17. (doi: 10.1128/AAC.01065-17) (PMID:28696240) (PMCID:PMC5571368)

Abstract

Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kean, Mr Ryan and Jones, Dr Brian and Sherry, Dr Leighann and Ramage, Professor Gordon and McKloud, Emily and Metcalfe, Rebecca and O'Donnell, Dr Lindsay
• Authors: Sherry, L., Kean, R., McKloud, E., O'Donnell, L. E., Metcalfe, R., Jones, B. L., and Ramage, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: Antimicrobial Agents and Chemotherapy
• Publisher: American Society for Microbiology
• ISSN: 0066-4804
• ISSN (Online): 1098-6596
• Published Online: 10 July 2017
• Copyright Holders: Copyright © 2017 American Society for Microbiology
• First Published: First published in Antimicrobial Agents and Chemotherapy 61(9): e01065-17
• Publisher Policy: Reproduced in accordance with the publisher copyright policy