Implications of antimicrobial combinations in complex wound biofilms containing fungi

Townsend, E. M., Sherry, L. , Kean, R., Hansom, D., Mackay, W. G., Williams, C., Butcher, J. and Ramage, G. (2017) Implications of antimicrobial combinations in complex wound biofilms containing fungi. Antimicrobial Agents and Chemotherapy, 61(9), e00672-17. (doi: 10.1128/AAC.00672-17) (PMID:28696230)

Abstract

Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while mono-treatment approaches influenced biofilm composition it had no discernible effect on overall quantity. Only by combining bacterial and fungal specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kean, Mr Ryan and Ramage, Professor Gordon and Williams, Dr Craig and Sherry, Dr Leighann and Townsend, Miss Eleanor
• Authors: Townsend, E. M., Sherry, L., Kean, R., Hansom, D., Mackay, W. G., Williams, C., Butcher, J., and Ramage, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: Antimicrobial Agents and Chemotherapy
• Publisher: American Society for Microbiology
• ISSN: 0066-4804
• ISSN (Online): 1098-6596
• Published Online: 10 July 2017
• Copyright Holders: Copyright © 2017 American Society for Microbiology
• First Published: First published in Antimicrobial Agents and Chemotherapy 61(9):e00672-17
• Publisher Policy: Reproduced in accordance with the publisher copyright policy