Gait analysis and quantitative drug effect evaluation in Parkinson disease by jointly EEG-EMG monitoring

De Venuto, D., Annese, V. F. , Defazio, G., Gallo, V.L. and Mezzina, G. (2017) Gait analysis and quantitative drug effect evaluation in Parkinson disease by jointly EEG-EMG monitoring. In: 2017 12th International Conference on Design & Technology of Integrated Systems In Nanoscale Era (DTIS), Palma de Mallorca, Spain, 04-06 Apr 2017, ISBN 9781509063789 (doi: 10.1109/DTIS.2017.7930171)

Abstract

This work addresses the rising need for a diagnostic tool for the evaluation of the effectiveness of a drug treatment in Parkinson disease, allowing the physician to monitor of the patient gait at home and to shape the treatment on the individual peculiarity. In aim, we present a cyber-physical system for real-time processing EEG and EMG signals. The wearable and wireless system extracts the following indexes: (i) typical activation and deactivation timing of single muscles and the duty cycle in a single step (ii) typical and maximum co-contractions, as well as number of co-contraction/s. The indexes are validated by using Movement Related Potentials (MRPs). The signal processing stage is implemented on Altera Cyclone V FPGA. In the paper, we show in vivo measurements by comparing responses before and after the drug (Levodopa) treatment. The system quantifies the effect of the Levodopa treatment detecting: (i) a 17% reduction in typical agonist-antagonist co-contractions time (ii) 23.6% decrease in the maximum co-contraction time (iii) 33% decrease in number of critical co-contraction. Brain implications shows a mean reduction of 5% on the evaluated potentials.

• Item Type: Conference Proceedings
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Annese, Dr Valerio
• Authors: De Venuto, D., Annese, V. F., Defazio, G., Gallo, V.L., and Mezzina, G.
• College/School: College of Science and Engineering > School of Engineering
• ISBN: 9781509063789
• Copyright Holders: Copyright © 2017 IEEE
• First Published: First published in 2017 12th International Conference on Design & Technology of Integrated Systems In Nanoscale Era (DTIS)
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher