Stroke, cognitive function, and Alzheimer’s disease

Jackman, K. A., Cumming, T. and Miller, A. A. (2016) Stroke, cognitive function, and Alzheimer’s disease. In: Lazarov, O. and Tesco, G. (eds.) Genes, Environment and Alzheimer's Disease. Elsevier, pp. 319-359. ISBN 9780128028513 (doi: 10.1016/B978-0-12-802851-3.00011-5)

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Ischemic stroke is a leading cause of death and disability worldwide. Perhaps more importantly, stroke can lead to various cognitive changes, referred to collectively as vascular cognitive impairment (VCI). In addition, stroke increases the risk of vascular dementia (VaD), which is the most frequently encountered dementia after Alzheimer’s disease (AD). Traditionally, the pathogenic causes and underlying mechanisms of VCI and AD have been considered separate entities. However, several lines of evidence now indicate an overlap between vascular and neurodegenerative causes of dementia. Indeed, vascular factors are now thought to be involved in both VCI and AD. Furthermore, clinical and experimental studies show that ischemic stroke increases the risk of AD, and may influence dementia expression by aggravating Alzheimer’s-associated neuropathology. In this chapter, we begin by briefly summarizing the pathogenesis of stroke, before highlighting current evidence for the involvement of vascular factors in both VCI and AD, with a particular focus on the neurovascular unit. Finally, we will discuss clinical and experimental evidence for poststroke VCI and AD.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Miller, Dr Alyson and Cumming, Dr Toby
Authors: Jackman, K. A., Cumming, T., and Miller, A. A.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Nursing and Health Care
Published Online:04 March 2016

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