Ardoña, H. A. M., Draper, E. R. , Citossi, F., Wallace, M., Serpell, L. C., Adams, D. J. and Tovar, J. D. (2017) Kinetically controlled coassembly of multichromophoric peptide hydrogelators and the impacts on energy transport. Journal of the American Chemical Society, 139(25), pp. 8685-8692. (doi: 10.1021/jacs.7b04006) (PMID:28578581)
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Abstract
We report a peptide-based multichromophoric hydrogelator system, wherein π-electron units with different inherent spectral energies are spatially controlled within peptidic 1-D nanostructures to create localized energy gradients in aqueous environments. This is accomplished by mixing different π-conjugated peptides prior to initiating self-assembly through solution acidification. We can vary the kinetics of the assembly and the degree of self-sorting through the choice of the assembly trigger, which changes the kinetics of acidification. The hydrolysis of glucono-δ-lactone (GdL) provides a slow pH drop that allows for stepwise triggering of peptide components into essentially self-sorted nanostructures based on subtle pKa differences, whereas HCl addition leads to a rapid formation of mixed components within a nanostructure. Using 1H NMR spectroscopy and fiber X-ray diffraction, we determine the conditions and peptide mixtures that favor self-sorting or intimate comixing. Photophysical investigations in the solution phase provide insight into the correlation of energy-transport processes occurring within the assemblies to the structural organization of the π-systems.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Draper, Emily and Adams, Dave |
| Authors: | Ardoña, H. A. M., Draper, E. R., Citossi, F., Wallace, M., Serpell, L. C., Adams, D. J., and Tovar, J. D. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Journal of the American Chemical Society |
| Publisher: | American Chemical Society |
| ISSN: | 0002-7863 |
| ISSN (Online): | 1520-5126 |
| Published Online: | 05 June 2017 |
| Copyright Holders: | Copyright © 2017 American Chemical Society |
| First Published: | First published in Journal of the American Chemical Society 139(25): 8685-8692 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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