Sensitivity to BST-2 restriction correlates with orthobunyavirus host range

Varela, M. et al. (2017) Sensitivity to BST-2 restriction correlates with orthobunyavirus host range. Virology, 509, pp. 121-130. (doi: 10.1016/j.virol.2017.06.017) (PMID:28628828) (PMCID:PMC5526858)

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Orthobunyaviruses include several recently emerging viruses of significant medical and veterinary importance. There is currently very limited understanding on what determines the host species range of these pathogens. In this study we discovered that BST-2/tetherin restricts orthobunyavirus replication in a host-specific manner. We show that viruses with human tropism (Oropouche virus and La Crosse virus) are restricted by sheep BST-2 but not by the human orthologue, while viruses with ruminant tropism (Schmallenberg virus and others) are restricted by human BST-2 but not by the sheep orthologue. We also show that BST-2 blocks orthobunyaviruses replication by reducing the amount of envelope glycoprotein into viral particles egressing from infected cells. This is the first study identifying a restriction factor that correlates with species susceptibility to orthobunyavirus infection. This work provides insight to help us dissect the adaptive changes that bunyaviruses require to cross the species barrier and emerge into new species.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Palmarini, Professor Massimo and Elliott, Professor Richard and Shi, Dr Xiaohong and Pinto, Dr Rute and Piras, Dr Ilaria and Taggart, Ms Aislynn and Kreher, Dr Felix and Mullan, Catrina and Varela, Dr Mariana
Authors: Varela, M., Piras, I. M., Mullan, C., Shi, X., Tilston-Lunel, N. L., Pinto, R. M., Taggart, A., Welch, S. R., Neil, S. J.D., Kreher, F., Elliott, R. M., and Palmarini, M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Virology
ISSN (Online):1096-0341
Published Online:17 June 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Virology 509: 121-130
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
501441Centre for Integrated VirologyMassimo PalmariniMedical Research Council (MRC)G0801822MVLS III - CENTRE FOR VIRUS RESEARCH