The relationship between tumour stage, systemic inflammation, body composition and survival in patients with colorectal cancer

McSorley, S. T. , Black, D. H., Horgan, P. G. and McMillan, D. C. (2018) The relationship between tumour stage, systemic inflammation, body composition and survival in patients with colorectal cancer. Clinical Nutrition, 37(4), pp. 1279-1285. (doi: 10.1016/j.clnu.2017.05.017) (PMID:28566220)

Abstract

Background: Disease progression in cancer is often associated with loss of weight and lean tissue and the development of a systemic inflammatory response (SIR) and these have prognostic value. The present study investigated the relationship between these factors in patients with operable colorectal cancer. Methods: The study included 322 patients with primary operable colorectal cancer. In addition to BMI, pre-operative CT scans were used to define the presence of visceral obesity, sarcopenia and myosteatosis. Tumour and patient characteristics were recorded. Survival was analysed using univariate and multivariate Cox regression. Results: There was no significant association between TNM stage and any measure of body composition. The modified Glasgow Prognostic Score (mGPS), was associated with greater BMI (p = 0.021), sarcopenia (p < 0.001), and myosteatosis (p = 0.004). On univariate analysis, there was a significant association between age (p = 0.002), ASA grade (p = 0.010), TNM stage (p < 0.001), mGPS (p = 0.001) and myosteatosis (p = 0.017) and disease specific survival. On multivariate analysis, age (HR 1.89, 95% CI 1.27–2.79, p = 0.002), TNM stage (HR 2.27, 95% CI 1.45–3.55, p < 0.001) and mGPS (HR 1.48, 95% CI 1.08–2.03, p = 0.016) remained prognostic. Conclusions: The SIR is a key hallmark of progressive nutritional and functional decline leading to poorer survival in patients with cancer.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Horgan, Professor Paul and McMillan, Professor Donald and McSorley, Dr Stephen
• Authors: McSorley, S. T., Black, D. H., Horgan, P. G., and McMillan, D. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Clinical Nutrition
• Publisher: Elsevier
• ISSN: 0261-5614
• ISSN (Online): 1532-1983
• Published Online: 19 May 2017
• Copyright Holders: Copyright © 2017 Elsevier Ltd. and European Society for Clinical Nutrition and Metabolism
• First Published: First published in Clinical Nutrition 37(4):1279-1285
• Publisher Policy: Reproduced in accordance with the publisher copyright policy