Minimally Invasive Optical Biopsy for Oximetry

van der Putten, M. A. , Brewer, J. M. and Harvey, A. R. (2017) Minimally Invasive Optical Biopsy for Oximetry. In: Endoscopic Microscopy XII, San Francisco, CA, USA, 29-30 Jan 2017, p. 1004009. (doi: 10.1117/12.2253645)

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The study of localised oxygen saturation in blood vessels can shed light on the etiology and progression of many diseases with which hypoxia is associated. For example, hypoxia in the tendon has been linked to early stages of rheumatoid arthritis, an auto-immune inflammatory disease. Vascular oximetry of deep tissue presents significant challenges as vessels are not optically accessible. In this paper, we present a novel multispectral imaging technique for vascular oximetry, and recent developments made towards its adaptation for minimally invasive imaging. We present proof-of-concept of the system and illumination scheme as well as the analysis technique. We present results of a validation study performed in vivo on mice with acutely inflamed tendons. Adaptation of the technique for minimally invasive microendoscopy is also presented, along with preliminary results of minimally invasive ex vivo vascular oximetry.

Item Type:Conference Proceedings
Additional Information:This work is funded by the University of Glasgow’s ‘Lord Kelvin Adam Smith’ scholarship for interdisciplinary research.
Glasgow Author(s) Enlighten ID:Brewer, Professor James and Harvey, Professor Andy and Van Der Putten, Miss Marieke
Authors: van der Putten, M. A., Brewer, J. M., and Harvey, A. R.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Science and Engineering > School of Physics and Astronomy
Copyright Holders:Copyright © 2017 SPIE
First Published:First published in Endoscopic Microscopy XII, Proceedings of SPIE 10040: 1004009
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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