Nunes-Neto, J. P. et al. (2017) Characterization of the Bujaru, frijoles and Tapara antigenic complexes into the sandfly fever group and two unclassified phleboviruses from Brazil. Journal of General Virology, 98(4), pp. 585-594. (doi: 10.1099/jgv.0.000724) (PMID:28141497)
Full text not currently available from Enlighten.
Abstract
The genus Phlebovirus includes the sandfly fever viruses and tick-transmitted uukuviruses. Sandfly fever group viruses have been isolated from various vertebrate species and from phlebotomines and occasionally alternative arthropods, e.g. mosquitoes, or ceratopogonids of the genus Culicoides. Uukuniemi serogroup viruses have been isolated from various vertebrate species and from ticks. Despite the public health importance of some viruses of the genus, the genomic diversity of phleboviruses that could be incriminated as causative of human or veterinary diseases remains underestimated. Here we describe the nearly complete sequences and genomic characterization of two phleboviruses belonging to the Bujaru antigenic complex: the prototype species and the Munguba virus. Furthermore, six previously unclassified phleboviruses isolated in Brazil were also sequenced and characterized: Ambe, Anhanga, Joa, Uriurana, Urucuri and Tapara viruses. The results of the phylogenetic analysis indicated that these viruses group with viruses of three antigenic complexes (Bujaru, Tapara and frijoles clades), with two unclassified phleboviruses. We also performed genomic reassortment analysis and confirmed that there were no events for the viruses described in this study, but we found a new potential reassortment in Medjerda Valley virus, which contains S and L segments of Arbia virus, and probably a unique M segment, both viruses circulate in the same geographic region, indicating these two isolates represent two distinct viruses. This study provides insights into the genetic diversity, classification and evolution of phleboviruses
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Souza, Mr William |
| Authors: | Nunes-Neto, J. P., Souza, W. M. d., Acrani, G. O., Romeiro, M. F., Fumagalli, M., Vieira, L. C., Medeiros, D. B. d., Lima, J. A., Lima, C. P. S. d., Cardoso, J. F., Figueiredo, L. T. M., Silva, S. P. d., Tesh, R., Nunes, M. R. T., and Vasconcelos, P. F. d. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of General Virology |
| Publisher: | Microbiology Society |
| ISSN: | 0022-1317 |
| ISSN (Online): | 1465-2099 |
| Published Online: | 28 April 2017 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric