A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

Peden, J. F. et al. (2011) A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nature Genetics, 43(4), pp. 339-344. (doi: 10.1038/ng.782) (PMID:21378988)

Abstract

Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)1, 2, 3, 4, 5, 6, 7, a modest number considering the apparent heritability of CAD8. All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with ~575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10−8 in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Strawbridge, Dr Rona
• Authors: Peden, J. F., Hopewell, J. C., Saleheen, D., Chambers, J. C., Hager, J., Soranzo, N., Collins, R., Danesh, J., Elliott, P., Farrall, M., Stirrups, K., Zhang, W., Hamsten, A., Parish, S., Lathrop, M., Watkins, H., Clarke, R., Deloukas, P., Kooner, J. S., Goel, A., Ongen, H., Strawbridge, R. J., Heath, S., Mälarstig, A., Helgadottir, A., Öhrvik, J., Murtaza, M., Potter, S., Hunt, S. E., Delepine, M., Jalilzadeh, S., Axelsson, T., Syvanen, A.-C., Gwilliam, R., Bumpstead, S., Gray, E., Edkins, S., Folkersen, L., Kyriakou, T., Franco-Cereceda, A., Gabrielsen, A., Seedorf, U., Eriksson, P., Offer, A., Bowman, L., Sleight, P., Armitage, J., Peto, R., Abecasis, G., Ahmed, N., Caulfield, M., Donnelly, P., Froguel, P., Kooner, A. S., McCarthy, M. I., Samani, N. J., Scott, J., Sehmi, J., Silveira, A., Hellénius, M.-L., van 't Hooft, F. M., Olsson, G., Rust, S., Assmann, G., Barlera, S., Tognoni, G., Franzosi, M. G., Linksted, P., Green, F. R., Rasheed, A., Zaidi, M., Shah, N., Samuel, M., Mallick, N. H., Azhar, M., Zaman, K. S., Samad, A., Ishaq, M., Gardezi, A. R., Memon, F.-u.-R., Frossard, P. M., Spector, T., Peltonen, L., Nieminen, M. S., Sinisalo, J., Salomaa, V., Ripatti, S., Bennett, D., Leander, K., Gigante, B., de Faire, U., Pietri, S., Gori, F., Marchioli, R., Sivapalaratnam, S., Kastelein, J. J. P., Trip, M. D., Theodoraki, E. V., Dedoussis, G. V., Engert, J. C., Yusuf, S., and Anand, S. S.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
• Journal Name: Nature Genetics
• Publisher: Nature Publishing Group
• ISSN: 1061-4036
• ISSN (Online): 1546-1718
• Published Online: 06 March 2011