Gigante, B. et al. (2014) Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men. Atherosclerosis, 236(2), pp. 394-399. (doi: 10.1016/j.atherosclerosis.2014.07.030) (PMID:25150937)
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Abstract
Objective: Low levels of IgM anti-phosphorylcholine (anti-PC) increase the risk of cardiovascular events (CVE). Here we investigate the association of low anti-PC with the progression of carotid intima media thickness (C-IMT) and incidence of CVE in a large cohort of individuals at high risk of CVE, the IMPROVE, a prospective multicenter European study. Methods: 3711 subjects (54–79 years) with at least three established cardiovascular risk factors were enrolled. Baseline serum levels of IgM anti-PC were measured by ELISA. Carotid ultrasound investigations were performed at baseline and after 15 and 30 months of follow-up. The risk of C-IMT progression and ischemic CVE associated with low anti-PC levels was tested by logistic regression and Cox regression analysis, respectively. Risk estimates were adjusted by center and conventional cardiovascular risk factors. Results: 3670 study participants were included in the present analysis and 213 CVE were recorded during a 3 year follow up. Anti-PC levels (U/ml) were classified into quartiles [Q1≤ 40, Q2 >40-≤64, Q3 >64-≤102, Q4 >102]. In men, low levels of anti-PC (Q1) were associated with the highest (>90th) percentile of the fastest C-IMT progression, i.e. the segment showing the fastest progression over 30 months in the whole carotid tree, with an OR of 1.41 (95%CI, 1.02–1.9) and with an increased risk of CVE with a multivariable adjusted HR of 1.85 (95%CI, 1.1–3.1). No significant associations were found in women. Conclusions: Low anti-PC levels increase the risk of CVE in men. This effect may be partly mediated by a fast C-IMT progression.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Strawbridge, Dr Rona |
Authors: | Gigante, B., Leander, K., Vikström, M., Baldassarre, D., Veglia, F., Strawbridge, R. J., McLeod, O., Gertow, K., Sennblad, B., Shah, S., Zabaneh, D., Humphries, S. E., Kauhanen, J., Rauramaa, R., Smit, A. J., Mannarino, E., Giral, P., Tremoli, E., Hamsten, A., Frostegård, J., and de Faire, U. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing |
Journal Name: | Atherosclerosis |
Publisher: | Elsevier |
ISSN: | 0021-9150 |
ISSN (Online): | 1879-1484 |
Published Online: | 05 August 2014 |
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