Newman, A. C. and Maddocks, O. D.K. (2017) One-carbon metabolism in cancer. British Journal of Cancer, 116(2), pp. 1499-1504. (doi: 10.1038/bjc.2017.118) (PMID:28472819) (PMCID:PMC5518849)
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Abstract
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells. As such, anti-folates, drugs that target one-carbon metabolism, have long been used in the treatment of cancer. Amino acids, such as serine are a major one-carbon source, and cancer cells are particularly susceptible to deprivation of one-carbon units by serine restriction or inhibition of de novo serine synthesis. Recent work has also begun to decipher the specific pathways and sub-cellular compartments that are important for one-carbon metabolism in cancer cells. In this review we summarise the historical understanding of one-carbon metabolism in cancer, describe the recent findings regarding the generation and usage of one-carbon units and explore possible future therapeutics that could exploit the dependency of cancer cells on one-carbon metabolism.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Newman, Dr Alice and Maddocks, Professor Oliver |
Authors: | Newman, A. C., and Maddocks, O. D.K. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | British Journal of Cancer |
Publisher: | Cancer Research UK |
ISSN: | 1532-1827 |
ISSN (Online): | 1532-1827 |
Published Online: | 04 May 2017 |
Copyright Holders: | Copyright © 2017 American Heart Association, Inc. |
First Published: | First published in British Journal of Cancer 116(2):1499-1504 |
Publisher Policy: | Reproduced under a Creative Commons License |
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