Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2017) Genomics of hypertension. Pharmacological Research, 121, pp. 219-229. (doi: 10.1016/j.phrs.2017.04.031) (PMID:28495658)
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Abstract
A complex network of interacting pathways involving renal, neural, endocrine, vascular and other mechanisms controls the main determinants of blood pressure – cardiac output and total peripheral resistance. Multiple genes within each of these systems contribute to the specialized functions regulating blood pressure. The monogenic forms of blood pressure dysregulation have provided valuable insights into blood pressure regulation and expanded our understanding of both the mechanisms and the treatment of hypertension. Genome wide association studies have identified over 100 single nucleotide polymorphisms associated with blood pressure phenotypes and have identified plausible novel pathways of BP regulation and putative drug targets.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Padmanabhan, Professor Sandosh and Dominiczak, Professor Anna and Aman, Ms Alisha |
| Authors: | Padmanabhan, S., Aman, A., and Dominiczak, A. F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Pharmacological Research |
| Publisher: | Elsevier |
| ISSN: | 1043-6618 |
| ISSN (Online): | 1096-1186 |
| Published Online: | 08 May 2017 |
| Copyright Holders: | Copyright © 2017 Elsevier |
| First Published: | First published in Pharmacological Research 121: 219-229 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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