Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells

Laté de Laté, P., Pineda, M. , Harnett, M. , Harnett, W., Besteiro, S. and Langsley, G. (2017) Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells. Biomedical Journal, 40(1), pp. 23-30. (doi: 10.1016/j.bj.2017.01.001) (PMID:28411879)

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Apicomplexan parasites are responsible for a number of important human pathologies. Obviously, as Eukaryotes they share a number of cellular features and pathways with their respective host cells. One of them is autophagy, a process involved in the degradation of the cell's own components. These intracellular parasites nonetheless seem to present a number of original features compared to their very evolutionarily distant host cells. In mammals and other metazoans, autophagy has been identified as an important contributor to the defence against microbial pathogens. Thus, host autophagy also likely plays a key role in the control of apicomplexan parasites, although its potential manipulation and subversion by intracellular parasites creates a complex interplay in the regulation of host and parasite autophagy. In this mini-review, we summarise current knowledge on autophagy in both parasites and their host cells, in the context of infection by three Apicomplexa: Plasmodium, Toxoplasma, and Theileria. [Abstract copyright: Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.]

Item Type:Articles
Additional Information:PLdL was supported by a ParaFrap post-doctoral fellowship. MAP is an Arthritis Research UK Career Development Fellow. SB and GL acknowledge support from ANR-11-LABX-0024 and the CNRS; SB acknowledges grant ANR-13-JSV3-0003 and GL acknowledges INSERM support.
Keywords:Autophagy, cell signalling, host cell, plasmodium, theileria, toxoplasma.
Glasgow Author(s) Enlighten ID:Harnett, Professor Margaret and Harnett, Professor William and Pineda, Dr Miguel
Authors: Laté de Laté, P., Pineda, M., Harnett, M., Harnett, W., Besteiro, S., and Langsley, G.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Biomedical Journal
ISSN (Online):2320-2890
Published Online:23 March 2017
Copyright Holders:Copyright © 2017 Chang Gung University
First Published:First published in Biomedical Journal 40(1): 23-30
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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