McGinty, S. , McCormick, C., McKittrick, C., Kennedy, S. , Oldroyd, K., Wheel, M., Scullion, B., Pontrelli, G. and McKee, S. (2017) Combining Mathematical Modelling with In-Vitro Experiments to Predict In-Vivo Drug-Eluting Stent Kinetics. In: 5 th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, PA, USA, 10-12 April 2017, pp. 1011-1014. ISBN 9780956291448
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Publisher's URL: http://www.compbiomed.net/2017/cmbe-proceedings.htm
Abstract
In this paper we describe a combined in-vitro experimental and mathematical modelling approach to predict in-vivo drug-eluting stent kinetics. We coated stents with a mixture of sirolimus and a novel acrylic-based polymer in two different ratios. Our results indicate differential release kinetics between low and high drug dose formulations. Furthermore, mathematical model simulations of target receptor saturation suggest potential differences in efficacy.
| Item Type: | Conference Proceedings |
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| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mcginty, Dr Sean and Oldroyd, Dr Keith and Kennedy, Professor Simon |
| Authors: | McGinty, S., McCormick, C., McKittrick, C., Kennedy, S., Oldroyd, K., Wheel, M., Scullion, B., Pontrelli, G., and McKee, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Science and Engineering > School of Engineering > Biomedical Engineering |
| ISSN: | 2227-3085 |
| ISBN: | 9780956291448 |
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