Anastasis, P., Freer, I., Overton, K. H., Picken, D., Rycroft, D. S. and Singh, S. B. (1987) On the role of leucine in terpenoid metabolism. Journal of the Chemical Society: Perkin Transactions 1, pp. 2427-2436. (doi: 10.1039/P19870002427)
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Abstract
Incorporation of [2-13C]-, [3-13C]-, (4R)-[5-13C]- and (4S)-[5-13C]-leucines into paniculide by tissue cultures of Andrographis paniculata shows that (a) (3S)-3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) from leucine breakdown is not incorporated direct into mevalonic acid (MVA) but that (b) both the acetyl-CoA and acetoacetate produced by leucine breakdown via HMG-CoA are subsequently incorporated into HMG-CoA and MVA.
Item Type: | Articles |
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Keywords: | Biosynthesis, natural product chemistry, NMR spectroscopy. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Rycroft, Dr David |
Authors: | Anastasis, P., Freer, I., Overton, K. H., Picken, D., Rycroft, D. S., and Singh, S. B. |
Subjects: | Q Science > QD Chemistry |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Journal of the Chemical Society: Perkin Transactions 1 |
Journal Abbr.: | J. Chem. Soc., Perkin Trans. 1 |
Publisher: | Royal Society of Chemistry |
ISSN: | 0300-922X |
ISSN (Online): | 2050-8255 |
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