The role of renal transporters and novel regulatory interactions in the TAL that control blood pressure

Graham, L. A., Dominiczak, A. and Ferreri, N. R. (2017) The role of renal transporters and novel regulatory interactions in the TAL that control blood pressure. Physiological Genomics, 49(5), pp. 261-276. (doi: 10.1152/physiolgenomics.00017.2017) (PMID:28389525)

Abstract

Hypertension (HTN), a major public health issue is currently the leading factor in the global burden of disease, where associated complications account for 9.4 million deaths worldwide every year (98). Excessive dietary salt intake is among the environmental factors that contribute to HTN, known as salt sensitivity. The heterogeneity of salt sensitivity and the multiple mechanisms that link high salt intake to increases in blood pressure are of upmost importance for therapeutic application. A continual increase in the kidney's reabsorption of sodium (Na+) relies on sequential actions at various segments along the nephron. When the distal segments of the nephron fail to regulate Na+, the effects on Na+ homeostasis are unfavourable. We propose that the specific nephron region where increased active uptake occurs as a result of variations in Na+ reabsorption is at the thick ascending limb of the loop of Henle (TAL). The purpose of this review is to urge the consideration of the TAL that contributes to the pathophysiology of salt sensitive HTN. Further research in this area will enable development of a therapeutic application for targeted treatment.

• Item Type: Articles
• Keywords: Thick ascending limb of the loop of Henle, hypertension, kidney, salt sensitivity, sodium.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Graham, Dr Lesley and Dominiczak, Professor Anna
• Authors: Graham, L. A., Dominiczak, A., and Ferreri, N. R.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Physiological Genomics
• Publisher: American Physiological Society
• ISSN: 1094-8341
• ISSN (Online): 1531-2267
• Published Online: 07 April 2017
• Copyright Holders: Copyright © 2017 The Authorsthe American Physiological Society
• First Published: First published in Physiological Genomics 49(5):261-276
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher