The 'cognitive footprint' of psychiatric and neurological conditions: cross-sectional study in the UK Biobank cohort

Cullen, B. , Smith, D.J. , Deary, I.J., Evans, J.J. and Pell, J.P. (2017) The 'cognitive footprint' of psychiatric and neurological conditions: cross-sectional study in the UK Biobank cohort. Acta Psychiatrica Scandinavica, 135(6), pp. 593-605. (doi: 10.1111/acps.12733) (PMID:28387438)

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Objective: We aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or Parkinson's disease, within a large general population cohort. Method: Cross-sectional study using UK Biobank data (n = 502 642). Psychiatric and neurological exposure status was ascertained via self-reported diagnoses, hospital records and questionnaires. Impairment on reasoning, reaction time and memory tests was defined with reference to a single unexposed comparison group. Results were standardised for age and gender. Sensitivity analyses examined the influence of comorbidity, education, information sources and missing data. Results: Relative to the unexposed group, cognitive impairment was least common in major depression (standardised prevalence ratios across tests = 1.00 [95% CI 0.98, 1.02] to 1.49 [95% CI 1.24, 1.79]) and most common in schizophrenia (1.89 [95% CI 1.47, 2.42] to 3.92 [95% CI 2.34, 6.57]). Prevalence in mania/bipolar was similar to that in multiple sclerosis and Parkinson's disease. Estimated population attributable prevalence of cognitive impairment was higher for major depression (256 per 100 000 [95% CI 130, 381]) than for all other disorders. Conclusion: Although the relative prevalence of cognitive impairment was lowest in major depression, the population attributable prevalence was highest overall for this group.

Item Type:Articles
Keywords:Cognitive dysfunction, mood disorders, neurological disorders, prevalence, schizophrenia.
Glasgow Author(s) Enlighten ID:Smith, Professor Daniel and Evans, Professor Jonathan and Cullen, Dr Breda and Pell, Professor Jill
Authors: Cullen, B., Smith, D.J., Deary, I.J., Evans, J.J., and Pell, J.P.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
Journal Name:Acta Psychiatrica Scandinavica
ISSN (Online):1600-0447
Published Online:07 April 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Acta Psychiatrica Scandinavica 135(6): 593-605
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
666301Cognitive outcomes in people with behavioural and brain disorders within UK BiobankBreda CullenScottish Executive Health Department (SEHHD-CSO)DTF/14/03IHW - MENTAL HEALTH & WELLBEING