The history of rabies in the Western Hemisphere

Velasco-Villa, A., Mauldin, M. R., Shi, M., Escobar, L. E., Gallardo-Romero, N. F., Damon, I., Olson, V. A., Streicker, D. G. and Emerson, G. (2017) The history of rabies in the Western Hemisphere. Antiviral Research, 146, pp. 221-232. (doi: 10.1016/j.antiviral.2017.03.013) (PMID:28365457) (PMCID:PMC5620125)

Abstract

Before the introduction of control programs in the 20th century, rabies in domestic dogs occurred throughout the Western Hemisphere. However, historical records and phylogenetic analysis of multiple virus isolates indicate that, before the arrival of the first European colonizers, rabies virus was likely present only in bats and skunks. Canine rabies was either rare or absent among domestic dogs of Native Americans, and first arrived when many new dog breeds were imported during the period of European colonization. The introduction of the cosmopolitan dog rabies lyssavirus variant and the marked expansion of the dog population provided ideal conditions for the flourishing of enzootic canine rabies. The shift of dog-maintained viruses into gray foxes, coyotes, skunks and other wild mesocarnivores throughout the Americas and to mongooses in the Caribbean has augmented the risk of human rabies exposures and has complicated control efforts. At the same time, the continued presence of bat rabies poses novel challenges in the absolute elimination of canine and human rabies. This article compiles existing historical and phylogenetic evidence of the origins and subsequent dynamics of rabies in the Western Hemisphere, from the era preceding the arrival of the first European colonizers through the present day. A companion article reviews the current status of canine rabies control throughout the Western Hemisphere and steps that will be required to achieve and maintain its complete elimination.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Streicker, Professor Daniel
• Authors: Velasco-Villa, A., Mauldin, M. R., Shi, M., Escobar, L. E., Gallardo-Romero, N. F., Damon, I., Olson, V. A., Streicker, D. G., and Emerson, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Antiviral Research
• Publisher: Elsevier
• ISSN: 0166-3542
• ISSN (Online): 1872-9096
• Published Online: 29 March 2017
• Copyright Holders: Copyright © 2017 The Authors
• First Published: First published in Antiviral Research 146:221-232
• Publisher Policy: Reproduced under a Creative Commons License