The sharing experimental animal resources, coordinating holdings (SEARCH) framework: encouraging reduction, replacement, and refinement in animal research

Morrissey, B., Blyth, K. , Carter, P., Chelala, C., Jones, L., Holen, I. and Speirs, V. (2017) The sharing experimental animal resources, coordinating holdings (SEARCH) framework: encouraging reduction, replacement, and refinement in animal research. PLoS Biology, 15(1), e2000719. (doi: 10.1371/journal.pbio.2000719) (PMID:28081116) (PMCID:PMC5230739)

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Abstract

While significant medical breakthroughs have been achieved through using animal models, our experience shows that often there is surplus material remaining that is frequently never revisited but could be put to good use by other scientists. Recognising that most scientists are willing to share this material on a collaborative basis, it makes economic, ethical, and academic sense to explore the option to utilise this precious resource before generating new/additional animal models and associated samples. To bring together those requiring animal tissue and those holding this type of archival material, we have devised a framework called Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) with the aim of making remaining material derived from animal studies in biomedical research more visible and accessible to the scientific community. We encourage journals, funding bodies, and scientists to unite in promoting a new way of approaching animal research by adopting the SEARCH framework.

Item Type:Articles
Additional Information:Funding: National Centre for the Replacement, Refinement and Reduction of Animals in Research https://www.nc3rs.org.uk/ (grant number NC/ L001004/1) received by VS. The Pathological Society of Great Britain and Ireland http://www. pathsoc.org/ (grant number OS2015 060 2) received by VS.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Blyth, Professor Karen
Authors: Morrissey, B., Blyth, K., Carter, P., Chelala, C., Jones, L., Holen, I., and Speirs, V.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:PLoS Biology
Publisher:Public Library of Science
ISSN:1544-9173
ISSN (Online):1545-7885
Copyright Holders:Copyright © 2017 Morrissey et al
First Published:First published in PLoS Biology 15(1): e2000719
Publisher Policy:Reproduced under a Creative Commons License

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