The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3

Vidal, V. et al. (2016) The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3. Genes and Development, 30(12), pp. 1389-1394. (doi: 10.1101/gad.277756.116) (PMID:27313319) (PMCID:PMC4926862)

Abstract

Adrenal glands are zonated endocrine organs that are essential in controlling body homeostasis. How zonation is induced and maintained and how renewal of the adrenal cortex is ensured remain a mystery. Here we show that capsular RSPO3 signals to the underlying steroidogenic compartment to induce β-catenin signaling and imprint glomerulosa cell fate. Deletion of RSPO3 leads to loss of SHH signaling and impaired organ growth. Importantly, Rspo3 function remains essential in adult life to ensure replenishment of lost cells and maintain the properties of the zona glomerulosa. Thus, the adrenal capsule acts as a central signaling center that ensures replacement of damaged cells and is required to maintain zonation throughout life.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: UNSPECIFIED
• Authors: Vidal, V., Sacco, S., Rocha, A. S., da Silva, F., Panzolini, C., Dumontet, T., Doan, T. M. P., Shan, J., Rak-Raszewska, A., Bird, T., Vainio, S., Martinez, A., and Schedl, A.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Genes and Development
• Publisher: Cold Spring Harbor Laboratory Press
• ISSN: 0890-9369
• ISSN (Online): 1549-5477
• Published Online: 16 June 2016
• Copyright Holders: Copyright © 2016 Vidal et al.
• First Published: First published in Genes and Development 30(12): 1389-1394
• Publisher Policy: Reproduced under a Creative Commons License