Chen, M.-Y., Insall, R. H. and Devreotes, P. N. (1996) Signaling through chemoattractant receptors in Dictyostelium. Trends in Genetics, 12(2), pp. 52-57. (doi: 10.1016/0168-9525(96)81400-4) (PMID:8851971)
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Abstract
Dictyostellium discoideum displays chemoattractant-directed cell migration typical of many higher cell types. Signalling through chemoattractant receptors involves a standard G-protein-linked pathway. Genetic analysis has distinguished essential and dispensable components and demonstrated that some signaling events are independent of G proteins. Genetic analysis has also led to the identification of additional genes involved in chemosensory transduction. Further studies on the newly discovered components and pathways should help in elucidating the molecular mechanisms of eukaryotic chemotaxis.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Insall, Professor Robert |
Authors: | Chen, M.-Y., Insall, R. H., and Devreotes, P. N. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Trends in Genetics |
Publisher: | Elsevier |
ISSN: | 0168-9525 |
ISSN (Online): | 1362-4555 |
Published Online: | 19 March 1999 |
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