Cardiopulmonary and sedative effects of intravenous or epidural methadone in conscious dogs

Vieira, B.H.B., Nishimura, L.T., Carvalho, L.L., Auckburally, A. and Mattos Junior, E. (2017) Cardiopulmonary and sedative effects of intravenous or epidural methadone in conscious dogs. Journal of Veterinary Pharmacology and Therapeutics, 40(6), e65-e68. (doi: 10.1111/jvp.12416) (PMID:28503730)

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Abstract

Cardiopulmonary and sedative effects of intravenous or epidural methadone were compared. Six beagles were randomly assigned to group MIV (methadone 0.5 mg/kg IV + NaCl 0.9% epidurally) or MEP (methadone 0.5 mg/kg epidurally + NaCl 0.9% IV). Cardiopulmonary, blood gas and sedation were assessed at time (T) 0, 15, 30, 60, 120, 240 and 480 min after drug administration. Compared to T0, heart rate decreased at T15–T120 in MIV (p < .001) and T15–T240 in MEP (p < .05); mean arterial pressure was reduced at T15–T60 in MEP (p < .01); respiratory rate was higher at T15 and T30 in both groups (p < .05); pH was lower at T15–T120 in MIV (p < .01) and T15, T30 and T120 in MEP (p < .05); PaCO2 was higher at T15–T60 in MIV (p < .01) and T15, T30 and T120 in MEP (p < .01); sedation scores were higher at T15 and T30 in MIV and T15–T60 in MEP (p < .05). At T120 and T240, sedation score was higher in group MEP compared with group MIV (p < .01) In conclusion, cardiopulmonary and sedative effects of identical methadone doses are similar when administered IV or epidurally to conscious healthy dogs.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Auckburally, Mr Adam
Authors: Vieira, B.H.B., Nishimura, L.T., Carvalho, L.L., Auckburally, A., and Mattos Junior, E.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Journal of Veterinary Pharmacology and Therapeutics
Publisher:Wiley
ISSN:0140-7783
ISSN (Online):1365-2885
Published Online:15 May 2017
Copyright Holders:Copyright © 2017 John Wiley and Sons Ltd
First Published:First published in Journal of Veterinary Pharmacology and Therapeutics 40(6): e65-e68
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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