Insall, R. H. and Weiner, O. D. (2001) PIP3, PIP2, and cell movement—similar messages, different meanings? Developmental Cell, 1(6), pp. 743-747. (doi: 10.1016/S1534-5807(01)00086-7) (PMID:11740936) (PMCID:PMC2819114)
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Abstract
The inositol lipids PI(4,5)P2 and PI(3,4,5)P3 are important regulators of actin polymerization, but their different temporal and spatial dynamics suggest that they perform separate roles. PI(3,4,5)P3 seems to act as an instructive second messenger, inducing local actin polymerization. PI(4,5)P2 appears to be present at too high a concentration and homogenous a distribution to fulfil a similar role. Instead, we suggest that PI(4,5)P2 acts permissively, restricting new actin polymerization to the region of the plasma membrane.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Insall, Professor Robert |
Authors: | Insall, R. H., and Weiner, O. D. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Developmental Cell |
Publisher: | Elsevier |
ISSN: | 1534-5807 |
ISSN (Online): | 1878-1551 |
Published Online: | 11 December 2001 |
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