Watton, P.N. , Selimovic, A., Raberger, N. B., Huang, P., Holzapfel, G. A. and Ventikos, Y. (2011) Modelling evolution and the evolving mechanical environment of saccular cerebral aneurysms. Biomechanics and Modeling in Mechanobiology, 10(1), pp. 109-132. (doi: 10.1007/s10237-010-0221-y) (PMID:20496095)
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Abstract
A fluid–solid-growth (FSG) model of saccular cerebral aneurysm evolution is developed. It utilises a realistic two-layered structural model of the internal carotid artery and explicitly accounts for the degradation of the elastinous constituents and growth and remodelling (G&R) of the collagen fabric. Aneurysm inception is prescribed: a localised degradation of elastin results in a perturbation in the arterial geometry; the collagen fabric adapts, and the artery achieves a new homeostatic configuration. The perturbation to the geometry creates an altered haemodynamic environment. Subsequent degradation of elastin is explicitly linked to low wall shear stress (WSS) in a confined region of the arterial domain. A sidewall saccular aneurysm develops, the collagen fabric adapts and the aneurysm stabilises in size. A quasi-static analysis is performed to determine the geometry at diastolic pressure. This enables the cyclic stretching of the tissue to be quantified, and we propose a novel index to quantify the degree of biaxial stretching of the tissue. Whilst growth is linked to low WSS from a steady (systolic) flow analysis, a pulsatile flow analysis is performed to compare steady and pulsatile flow parameters during evolution. This model illustrates the evolving mechanical environment for an idealised saccular cerebral aneurysm developing on a cylindrical parent artery and provides the guidance to more sophisticated FSG models of aneurysm evolution which link G&R to the local mechanical stimuli of vascular cells.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Watton, Dr Paul |
| Authors: | Watton, P.N., Selimovic, A., Raberger, N. B., Huang, P., Holzapfel, G. A., and Ventikos, Y. |
| College/School: | College of Science and Engineering > School of Mathematics and Statistics > Mathematics |
| Journal Name: | Biomechanics and Modeling in Mechanobiology |
| Publisher: | Springer |
| ISSN: | 1617-7959 |
| ISSN (Online): | 1617-7940 |
| Published Online: | 23 May 2010 |
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