Welsh, P. , Grassia, G., Botha, S., Sattar, N. and Maffia, P. (2017) Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? British Journal of Pharmacology, 174(22), pp. 3898-3913. (doi: 10.1111/bph.13818) (PMID:28409825) (PMCID:PMC5660005)
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Abstract
Data from basic science experiments is overwhelmingly supportive of the causal role of immune-inflammatory response(s) at the core of atherosclerosis, and therefore the theoretical potential to manipulate the inflammatory response to prevent cardiovascular events. However, extrapolation to humans requires care and we still lack definitive evidence to show that interfering in immune-inflammatory processes may safely lessen clinical atherosclerosis. In this review, we discuss key therapeutic targets in the treatment of vascular inflammation, placing basic research in to a wider clinical perspective, as well as identifying outstanding questions.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Maffia, Professor Pasquale and Welsh, Professor Paul and Grassia, Dr Gianluca and Botha, Dr Shani and Sattar, Professor Naveed |
| Authors: | Welsh, P., Grassia, G., Botha, S., Sattar, N., and Maffia, P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | British Journal of Pharmacology |
| Publisher: | Wiley |
| ISSN: | 0007-1188 |
| ISSN (Online): | 1476-5381 |
| Published Online: | 13 April 2017 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in British Journal of Pharmacology 174(22): 3898-3913 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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