Insall, R. (2003) Protein conformation: through a lens, darkly. Biochemical Journal, 372(1), e1-e2. (doi: 10.1042/bj20030358COM) (PMID:12939165)
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Abstract
This commentary describes the study by Calleja and co-workers, who have used fluorescence resonance energy transfer between two fluorescent proteins fused to one protein kinase (protein kinase B/Akt) to reveal conformational changes in a functional protein. The findings of their study offer an intriguing insight into the behaviour of an enzyme that is essential for multiple aspects of mammalian signalling.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Insall, Professor Robert |
| Authors: | Insall, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Biochemical Journal |
| Publisher: | Portland Press |
| ISSN: | 0264-6021 |
| ISSN (Online): | 1470-8728 |
| Published Online: | 15 May 2003 |
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