High resolution microultrasound (μUS) investigation of the gastrointestinal (GI) tract

Anbarasan, T., Démoré, C., Lay, H. , Sunoqrot, M. R.S., Poltarjonoks, R., Cochran, S. and Cox, B. F. (2017) High resolution microultrasound (μUS) investigation of the gastrointestinal (GI) tract. In: Prickril, B. and Rasooly, A. (eds.) Biosensors and Biodetection: Methods and Protocols, Volume 2: Electrochemical, Bioelectronic, Piezoelectric, Cellular and Molecular Biosensors. Series: Methods in molecular biology (1572). Springer, pp. 541-561. ISBN 9781493969104 (doi: 10.1007/978-1-4939-6911-1_34)

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Abstract

High resolution, microultrasound (μUS) scanning of the gastrointestinal (GI) tract has potential as an important transmural imaging modality to aid in diagnosis. Operating at higher frequencies than conventional clinical ultrasound instruments, μUS is capable of providing scanned images of the GI tract with higher resolution. To investigate the use of μUS for this application, a phantom which is cost effective, within ethical guidelines and, most importantly, similar in histology to the human GI tract is necessary. Therefore, a phantom utilizing porcine small bowel tissue has been developed for custom assembled μUS scanning systems. Two such systems, a stepping scanner and a continuous sweep scanner were utilized to repeatedly scan regions of prepared samples of porcine small bowel tissue. The porcine small bowel tissue phantom was perfused with degassed phosphate buffer saline (dPBS) solution through a cannula inserted in its mesenteric vessel to simulate in vivo conditions and achieve better μUS mucosal characterization. The μUS system scans a transducer across the tissue phantom to acquire RF echo data, which is then processed using MATLAB. A B-scan reconstruction produces 2D images with relative echo strength mapped to a color map of the user's choice. The phantom developed also allows for modifications such as the insertion of fiducial markers to detect tissue change over time and simultaneous perfusion and scanning, providing a platform for more detailed research and investigation into μUS scanning of the GI tract.

Item Type:Book Sections
Keywords:Gastrointestinal tract, High resolution ultrasound, Microultrasound, Phantom development, Porcine small bowel tissue.
Status:Published
Glasgow Author(s) Enlighten ID:Cox, Dr Benjamin F and Cochran, Professor Sandy and Lay, Dr Holly and Demore, Dr Christine
Authors: Anbarasan, T., Démoré, C., Lay, H., Sunoqrot, M. R.S., Poltarjonoks, R., Cochran, S., and Cox, B. F.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
Publisher:Springer
ISBN:9781493969104
Published Online:16 March 2017

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