Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?

Olson, M.F. (1996) Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease? Journal of Molecular Medicine, 74(10), pp. 563-571. (doi:10.1007/s001090050060) (PMID:8912177)

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Abstract

The Rho family of low molecular weight GTP-binding proteins control important aspects of cell shape, adhesion, movement and growth. The DBL-homology (DH) protein family of upstream regulators of Rho GTPases has recently been identified, and deregulated expression of these proteins can have dramatic cellular consequences. This review examines the possible role of DH proteins and Rho GTPases in oncogenesis, metastasis and development.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Olson, Professor Michael
Authors: Olson, M.F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Molecular Medicine
Publisher:Springer
ISSN:0946-2716
ISSN (Online):1432-1440

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