Julian, L. and Olson, M. F. (2014) Rho-associated coiled-coil containing kinases (ROCK). Small GTPases, 5(2), e29846. (doi: 10.4161/sgtp.29846) (PMID:25010901) (PMCID:PMC4114931)
Full text not currently available from Enlighten.
Abstract
Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase. They belong to the AGC family of serine/threonine kinases and play vital roles in facilitating actomyosin cytoskeleton contractility downstream of RhoA and RhoC activation. Since their discovery, ROCK kinases have been extensively studied, unveiling their manifold functions in processes including cell contraction, migration, apoptosis, survival, and proliferation. Two mammalian ROCK homologs have been identified, ROCK1 (also called ROCK I, ROKβ, Rho-kinase β, or p160ROCK) and ROCK2 (also known as ROCK II, ROKα, or Rho kinase), hereafter collectively referred to as ROCK. In this review, we will focus on the structure, regulation, and functions of ROCK.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by Cancer Research UK. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Olson, Professor Michael |
| Authors: | Julian, L., and Olson, M. F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Small GTPases |
| Publisher: | Taylor & Francis |
| ISSN: | 2154-1248 |
| ISSN (Online): | 2154-1256 |
| Published Online: | 31 October 2014 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric